#
160;Del.icio.us#160;Del.icio.us1 LEDAC, CNRS 5538, Institut A. Bonniot, Université J. Fourier, Grenoble, France
2 Galderma R et D, Sophia Antipolis, France
author email corresponding author email
BMC Dermatology 2002, 2:7doi:10.1186/1471-5945-2-7
The electronic version of this article is the complete one and can be found online at: 1471-5945/2/7
| Received: | 22 October 2001 |
| Accepted: | 29 April 2002 |
| Published: | 29 April 2002 |
© 2002 Thélu et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Epidermal homeostasis involves the monitoring of continuous proliferative and differentiative processes as keratinocytes migrate from the basal layer to the skin surface. Recently, differentiation of epidermal stem cells was shown to be promoted by the Notch pathway. This pathway is characterised by cell-cell interactions between transmembrane proteins and was first implicated in lateral inhibition, patterning and cell binary choices during embryogenesis.
By in situ hybridisation, we investigated the in vivo expression of related genes, namely; Notch 1–3, Delta 1, Jagged 1, Lunatic Fringe, Radical Fringe and Manic Fringe during keratinocyte proliferation and differentiation in humans in basal cell carcinoma, psoriasis and in wound healing experiments, compared with normal adult skin.